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    Antimicrob Agents Chemother. 2009 May;53(5):2189-91. Epub 2009 Feb 23.

    Early postpartum pharmacokinetics of lopinavir initiated intrapartum in Thai women.

    Cressey TR, Van Dyke R, Jourdain G, Puthanakit T, Roongpisuthipong A, Achalapong J, Yuthavisuthi P, Prommas S, Chotivanich N, Maupin R, Smith E, Shapiro DE, Mirochnick M; IMPAACT P1032 Team.

    Collaborators (79)

    Van Dyke R, Jourdain G, Maupin R Jr, Smith E, Watts H, Gardella J, Akinsanya L, Shapiro DE, Britto P, Shannon M, Sukrakanchana PO, Zimmer B, Frenkel L, Ngo-Giang-Huong N, Scott WA, Tran P, Mirochnick M, Cressey TR, Melvin A, Kabat B, Behm T, Ashton C, Dickover R, McIntosh K, Roongpisuthipong A, Dipoalo V, Martinez M, Snowden W, Conner C, Puthanakit T, Sirisanthana V, Aurpibul L, Khamrong C, Kosachunhanan N, Rungruengthanakit K, Vanprapar N, Chokephaibulkit K, Roongpisuthipong A, Prasitseubsai W, Anansakunwatt W, Puthavathana P, Seetapun N, Kongstan N, Noisumdaeng P, Lallemant M, Jourdain G, Ngo-Giang-Huong N, Cressey TR, Sukrakanchana PO, Than-in-at K, Chinwong D, Krapunpongsakul N, Yenjai W, Wongsrisai R, Thonglo J, Timakahan T, Taworn Y, Tanasri S, Kantipong P, Achalapong J, Sophon A, Thaweesombat Y, Kumluang C, Bowonwatanuwong C, Chotivanich N, Argadamnuy L, Chaisiri K, Yothipitak P, Matchua S, Yuthavisuthi P, Chanasit U, Greetanukroh P, Srisupaluk S, Kerdprasert P, Impoolsup N, Promma S, Kerdprasert P, Thitathan M, Taweewattanapan T.

    Source

    Harvard School of Public Health, Boston, Massachusetts, USA. tim@phpt.org

    Abstract

    Lopinavir (LPV) exposure is reduced during the third trimester of pregnancy. We report the pharmacokinetics of standard LPV-ritonavir dosing (400/100 mg twice daily) in the immediate and early postpartum period when initiated during labor. In 16 human immunodeficiency virus-infected Thai women, the median (range) LPV area under the concentration-time curve and maximum and minimum concentrations in plasma were 99.7 (66.1 to 180.5) microg x h/ml, 11.2 (8.0 to 17.5) microg/ml, and 4.6 (1.7 to 12.5) microg/ml, respectively, at 41 (12 to 74) h after delivery. All of the women attained adequate LPV levels through 30 days postpartum. No serious adverse events were reported.

    PMID:
    19237646
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2681511
    Free PMC Article

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