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    Curr Opin Chem Biol. 2009 Feb;13(1):10-8. Epub 2009 Feb 23.

    Enzyme (re)design: lessons from natural evolution and computation.

    Gerlt JA, Babbitt PC.

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    Departments of Biochemistry and Chemistry, University of Illinois, Urbana, 61801, United States. j-gerlt@uiuc.edu

    Abstract

    The (re)design of enzymes to catalyze 'new' reactions is a topic of considerable practical and intellectual interest. Directed evolution (random mutagenesis followed by screening/selection) has been used widely to identify novel biocatalysts. However, 'rational' approaches using either natural divergent evolution or computational predictions based on chemical principles have been less successful. This review summarizes recent progress in evolution-based and computation-based (re)design.

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    PMID:
    19237310
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2711627
    Free PMC Article

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