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Angew Chem Int Ed Engl. 2009;48(14):2518-21. doi: 10.1002/anie.200804326.

Detection and analysis of low-abundance cell-surface biomarkers using enzymatic amplification in microfluidic droplets.

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  • 1Department of Nano Biotechnology, Royal Institute of Technology, AlbaNova University Center, 10691 Stockholm, Sweden.


Finding the few: Cell-surface proteins are useful disease biomarkers, but current high-throughput methods are limited to detecting cells expressing more than several hundred proteins. Enzymatic amplification in microfluidic droplets (see picture) is a high-throughput method for detection and analysis of cell-surface biomarkers expressed at very low levels on individual human cells. Droplet optical labels allow concurrent analysis of several samples.

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