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J Immunol. 2009 Mar 1;182(5):2578-82. doi: 10.4049/jimmunol.0803162.

Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells.

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  • 1Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom.

Abstract

Foxp3 is a transcription factor that is essential for the normal development of regulatory T cells (Tregs). In the absence of microRNAs (miRNAs), Foxp3(+) Tregs develop but fail to maintain immune homeostasis, leading to a scurfy-like disease. Global analysis of the network of genes regulated by Foxp3 has identified the miRNA miR-155, which is highly expressed in Tregs, as a direct target of Foxp3. In this study we report that miR-155-deficient mice have reduced numbers of Tregs, both in the thymus and periphery, due to impaired development. However, we found no evidence for defective suppressor activity of miR-155-deficient Tregs, either in vitro or in vivo. Our results indicate that miR-155 contributes to Treg development, but that additional miRNAs control Treg function.

PMID:
19234151
[PubMed - indexed for MEDLINE]
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