Display Settings:

Format

Send to:

Choose Destination
Blood. 2009 Apr 16;113(16):3679-81. doi: 10.1182/blood-2008-10-184705. Epub 2009 Feb 20.

Malignant mesothelioma after radiation treatment for Hodgkin lymphoma.

Author information

  • 1Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam.

Abstract

Malignant mesothelioma is a relatively uncommon malignancy. Although the pathogenesis is primarily related to asbestos, the disease may be associated with radiation exposure. Recently, increased risks for second primary mesothelioma after radiation for lymphoma have been reported. Because these findings are based on small numbers of patients, they need to be confirmed. We examined mesothelioma risk in 2567 5-year survivors of Hodgkin lymphoma. The risk was almost 30-fold increased in Hodgkin lymphoma patients treated with irradiation compared with the general population. Although histology and survival of the mesothelioma cases were comparable with cases from the general population, asbestos exposure and the proportion of males were lower than expected. The evidence for radiotherapy as cause for mesothelioma independent of exposure to asbestos is expanding, and the diagnosis of mesothelioma should be kept in mind whenever related symptoms arise in patients who had previous irradiation.

Comment in

  • Consistency and synergy. [Blood. 2009]
PMID:
19234144
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk