Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
DNA Repair (Amst). 2009 Apr 5;8(4):517-24. doi: 10.1016/j.dnarep.2009.01.010. Epub 2009 Feb 23.

Genome stability roles of SUMO-targeted ubiquitin ligases.

Author information

  • 1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

Post-translational modification of the cell's proteome by ubiquitin and ubiquitin-like proteins provides dynamic functional regulation. Ubiquitin and SUMO are well-studied post-translational modifiers that typically impart distinct effects on their targets. The recent discovery that modification by SUMO can target proteins for ubiquitination and proteasomal degradation sets a new paradigm in the field, and offers insights into the roles of SUMO and ubiquitin in genome stability.

PMID:
19233742
[PubMed - indexed for MEDLINE]
PMCID:
PMC2685196
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 1
Figure 2
Figure 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk