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DNA Repair (Amst). 2009 Apr 5;8(4):517-24. doi: 10.1016/j.dnarep.2009.01.010. Epub 2009 Feb 23.

Genome stability roles of SUMO-targeted ubiquitin ligases.

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  • 1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.


Post-translational modification of the cell's proteome by ubiquitin and ubiquitin-like proteins provides dynamic functional regulation. Ubiquitin and SUMO are well-studied post-translational modifiers that typically impart distinct effects on their targets. The recent discovery that modification by SUMO can target proteins for ubiquitination and proteasomal degradation sets a new paradigm in the field, and offers insights into the roles of SUMO and ubiquitin in genome stability.

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