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    FEBS Lett. 2009 Mar 18;583(6):960-4. Epub 2009 Feb 20.

    Identification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome system.

    Zhang J, Sarge KD.

    Graduate Center for Toxicology, Chandler Medical Center, University of Kentucky, Lexington, KY 40536, USA.

    Bmi-1 is a polycomb protein that plays an important role in tumor cell development and maintaining stem cell populations of many cell lineages. Here we identify a polymorphism in human Bmi-1 that changes a cysteine within its RING domain to tyrosine. This C18Y polymorphism is associated with a significant decrease in Bmi-1 level and its elevated ubiquitination, suggesting that it is being destroyed by the ubiquitin-proteasome system. Consistent with this, treating cells with the proteasome inhibitor MG-132 significantly increases C18Y Bmi-1 levels. This is the first example of a polymorphism in Bmi-1 that reduces levels of this important protein.

    PMID: 19233177 [PubMed - indexed for MEDLINE]

    PMCID: 2657319

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