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Institut für Theoretische Physik, Universität zu Köln, Zülpicherstrasse 77, 50937 Köln, Germany. vimuston@thp.uni-koeln.de
Evolution is a quest for innovation. Organisms adapt to changing natural selection by evolving new phenotypes. Can we read this dynamics in their genomes? Not every mutation under positive selection responds to a change in selection: beneficial changes also occur at evolutionary equilibrium, repairing previous deleterious changes and restoring existing functions. Adaptation, by contrast, is viewed here as a non-equilibrium phenomenon: the genomic response to time-dependent selection. Our approach extends the static concept of fitness landscapes to dynamic fitness seascapes. It shows that adaptation requires a surplus of beneficial substitutions over deleterious ones. Here, we focus on the evolution of yeast and Drosophila genomes, providing examples where adaptive evolution can and cannot be inferred, despite the presence of positive selection.
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