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Cell Biol Int. 2009 Apr;33(4):453-65. doi: 10.1016/j.cellbi.2009.02.001. Epub 2009 Feb 20.

TNF superfamily: costimulation and clinical applications.

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  • 1Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA.

Abstract

The molecules concerned with costimulation belong either to the immunoglobulin (Ig) or tumor necrosis factor (TNF) superfamily. The tumor necrosis superfamily comprises molecules capable of providing both costimulation and cell death. In this review we briefly summarize certain TNF superfamily receptor-ligand pairs that are endowed with costimulatory properties and their importance in health and disease.

PMID:
19230849
[PubMed - indexed for MEDLINE]
PMCID:
PMC2712666
Free PMC Article
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