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Bioinformatics. 2009 Apr 15;25(8):1078-9. doi: 10.1093/bioinformatics/btp091. Epub 2009 Feb 19.

Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.

Author information

  • 1Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA. bnilsson@broad.mit.edu

Abstract

MOTIVATION:

Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size.

RESULTS:

We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy.

PMID:
19228802
[PubMed - indexed for MEDLINE]
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