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Genome Biol. 2009;10(1):201. doi: 10.1186/gb-2009-10-1-201. Epub 2009 Jan 30.

Identifying protein-coding genes in genomic sequences.

Author information

  • 1Wellcome Trust Sanger Institute, Wellcome Trust Campus, Hinxton, Cambridge, UK.

Abstract

The vast majority of the biology of a newly sequenced genome is inferred from the set of encoded proteins. Predicting this set is therefore invariably the first step after the completion of the genome DNA sequence. Here we review the main computational pipelines used to generate the human reference protein-coding gene sets.

PMID:
19226436
[PubMed - indexed for MEDLINE]
PMCID:
PMC2687780
Free PMC Article

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