High-density peptide arrays

Mol Biosyst. 2009 Mar;5(3):224-34. doi: 10.1039/b819850k. Epub 2009 Jan 16.

Abstract

Arrays promise to advance biology by allowing parallel screening for many different binding partners. Meanwhile, lithographic methods enable combinatorial synthesis of > 50,000 oligonucleotides per cm(2), an advance that has revolutionized the whole field of genomics. A similar development is expected for the field of proteomics, provided that affordable, very high-density peptide arrays are available. However, peptide arrays lag behind oligonucleotide arrays. This review discusses recent developments in the field with an emphasis on methods that lead to very high-density peptide arrays.

Publication types

  • Review

MeSH terms

  • Combinatorial Chemistry Techniques
  • Peptides / chemical synthesis*
  • Protein Array Analysis*
  • Proteins / chemical synthesis

Substances

  • Peptides
  • Proteins