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Nature. 2009 Feb 19;457(7232):977-80. doi: 10.1038/nature07749.

A hierarchical model for evolution of 23S ribosomal RNA.

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  • 1Département de Biochimie, Université de Montréal, Montréal, H3C 3J7 (Québec), Canada.


The emergence of the ribosome constituted a pivotal step in the evolution of life. This event happened nearly four billion years ago, and any traces of early stages of ribosome evolution are generally thought to have completely eroded away. Surprisingly, a detailed analysis of the structure of the modern ribosome reveals a concerted and modular scheme of its early evolution.

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