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    Anim Genet. 2009 Jun;40(3):323-32. Epub 2009 Feb 16.

    Genetic diversity of dog breeds: within-breed diversity comparing genealogical and molecular data.

    Source

    AgroParisTech, UMR1236 Génétique et Diversité Animales, Paris, France. gregoire.leroy@agroparistech.fr

    Abstract

    The genetic diversity of 61 dog breeds raised in France was investigated. Genealogical analyses were performed on the pedigree file of the French kennel club. A total of 1514 dogs were also genotyped using 21 microsatellite markers. For animals born from 2001 to 2005, the average coefficient of inbreeding ranged from 0.2% to 8.8% and the effective number of ancestors ranged from 9 to 209, according to the breed. The mean value of heterozygosity was 0.62 over all breeds (range 0.37-0.77). At the breed level, few correlations were found between genealogical and molecular parameters. Kinship coefficients and individual similarity estimators were, however, significantly correlated, with the best mean correlation being found for the Lynch & Ritland estimator (r = 0.43). According to both approaches, it was concluded that special efforts should be made to maintain diversity for three breeds, namely the Berger des Pyrénées, Braque Saint-Germain and Bull Terrier.

    PMID:
    19222437
    [PubMed - indexed for MEDLINE]

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