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World J Gastroenterol. 2009 Feb 14;15(6):648-74.

Pediatric liver transplantation.

Author information

  • 1Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione-IsMeTT, Via E. Tricomi 1, 90127 Palermo, Italy. mspada@ismett.edu

Abstract

In previous decades, pediatric liver transplantation has become a state-of-the-art operation with excellent success and limited mortality. Graft and patient survival have continued to improve as a result of improvements in medical, surgical and anesthetic management, organ availability, immunosuppression, and identification and treatment of postoperative complications. The utilization of split-liver grafts and living-related donors has provided more organs for pediatric patients. Newer immunosuppression regimens, including induction therapy, have had a significant impact on graft and patient survival. Future developments of pediatric liver transplantation will deal with long-term follow-up, with prevention of immunosuppression-related complications and promotion of as normal growth as possible. This review describes the state-of-the-art in pediatric liver transplantation.

PMID:
19222089
[PubMed - indexed for MEDLINE]
PMCID:
PMC2653434
Free PMC Article

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