Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
FEMS Yeast Res. 2009 Mar;9(2):240-6. doi: 10.1111/j.1567-1364.2008.00469.x.

Bdf1p deletion affects mitochondrial function and causes apoptotic cell death under salt stress.

Author information

  • 1State Key Laboratory of Microbial Technology, Shandong University, Jinan, China.

Abstract

The Saccharomyces cerevisiae BDF1 gene encodes a bromodomain-containing transcription factor. We previously reported that deletion of Bdf1p in yeast cells resulted in increased sensitivity to NaCl stress. In this paper, we show that the function of Bdf1p in salt tolerance is not directly linked with the Ena1p-mediated Na(+) extrusion system, and a number of other well-characterized stress-response pathways. Interestingly, however, our data demonstrate that, under the NaCl stress, the absence of Bdf1p leads to mitochondrial dysfunction, including decreasing of mitochondrial membrane potential (Delta Psi) and accumulation of reactive oxygen species, and chromatin fragmentation and condensation. These results indicate that the bromodomain-containing protein, Bdf1p, is involved in the regulation of apoptosis in yeast cells.

PMID:
19220868
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk