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Headache. 2009 Jun;49(6):914-6. doi: 10.1111/j.1526-4610.2009.01344.x. Epub 2009 Feb 11.

Cluster attacks responsive to recreational cannabis and dronabinol.

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  • 1Montefiore Headache Center, Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Abstract

Pharmacological preparations of cannabinoid compounds have a variety of therapeutic uses in medicine, including different pain syndromes, but have not been previously reported as beneficial for cluster headache. We present a patient with cluster headache who was refractory to multiple acute and preventive medications but successfully aborted his attacks with recreational marijuana use; subsequent use of dronabinol provided equally effective pain relief. The beneficial effect may be related to the high concentration of cannabinoid receptors in the hypothalamus, which has been implicated as a site of dysfunction in neuroimaging studies of patients with cluster headache.

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PMID:
19220500
[PubMed - indexed for MEDLINE]
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