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Biom J. 2009 Feb;51(1):84-97. doi: 10.1002/bimj.200810494.

Finite mixture models for mapping spatially dependent disease counts.

Author information

  • 1Dipartimento di Statistica, Sapienza - Università di Roma, Italy. marco.alfo@uniroma1.it

Abstract

A vast literature has recently been concerned with the analysis of variation in disease counts recorded across geographical areas with the aim of detecting clusters of regions with homogeneous behavior. Most of the proposed modeling approaches have been discussed for the univariate case and only very recently spatial models have been extended to predict more than one outcome simultaneously. In this paper we extend the standard finite mixture models to the analysis of multiple, spatially correlated, counts. Dependence among outcomes is modeled using a set of correlated random effects and estimation is carried out by numerical integration through an EM algorithm without assuming any specific parametric distribution for the random effects. The spatial structure is captured by the use of a Gibbs representation for the prior probabilities of component membership through a Strauss-like model. The proposed model is illustrated using real data.

2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PMID:
19219904
[PubMed - indexed for MEDLINE]

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