Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cancer Invest. 2009 May;27(4):402-6. doi: 10.1080/07357900802406327.

Phase I study of weekly cisplatin, bolus fluorouracil and escalating doses of irinotecan in advanced solid tumors.

Author information

  • 1Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Abstract

PURPOSE:

We performed a phase I study of 5-fluorouracil (5-FU), cisplatin and irinotecan.

METHODS:

Twenty-nine patients received cisplatin 25 mg/m(2) and bolus 5-FU 425 mg/m(2), along with irinotecan at 40, 50, and 65 mg/m(2) weekly for 4 out of 6 weeks.

RESULTS:

The maximum tolerated dose (MTD) for untreated patients was irinotecan 65 mg/m(2) while the MTD for previously treated patients was irinotecan 40 mg/m(2). Neutropenia and diarrhea were the major dose-limiting toxicities. Antitumor activity was noted in gastric, esophageal and pancreatic cancers.

CONCLUSION:

Because of the toxicity profile, combinations with continuous infusion 5-FU or capecitabine should be explored.

PMID:
19219674
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Informa Healthcare
    Loading ...
    Write to the Help Desk