Source
Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Abstract
PURPOSE:
We performed a phase I study of 5-fluorouracil (5-FU), cisplatin and irinotecan.
METHODS:
Twenty-nine patients received cisplatin 25 mg/m(2) and bolus 5-FU 425 mg/m(2), along with irinotecan at 40, 50, and 65 mg/m(2) weekly for 4 out of 6 weeks.
RESULTS:
The maximum tolerated dose (MTD) for untreated patients was irinotecan 65 mg/m(2) while the MTD for previously treated patients was irinotecan 40 mg/m(2). Neutropenia and diarrhea were the major dose-limiting toxicities. Antitumor activity was noted in gastric, esophageal and pancreatic cancers.
CONCLUSION:
Because of the toxicity profile, combinations with continuous infusion 5-FU or capecitabine should be explored.