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Nat Neurosci. 2009 Mar;12(3):256-8. doi: 10.1038/nn.2271. Epub 2009 Feb 15.

Beyond extinction: erasing human fear responses and preventing the return of fear.

Author information

  • 1Department of Clinical Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, The Netherlands. m.kindt@uva.nl

Abstract

Animal studies have shown that fear memories can change when recalled, a process referred to as reconsolidation. We found that oral administration of the beta-adrenergic receptor antagonist propranolol before memory reactivation in humans erased the behavioral expression of the fear memory 24 h later and prevented the return of fear. Disrupting the reconsolidation of fear memory opens up new avenues for providing a long-term cure for patients with emotional disorders.

PMID:
19219038
[PubMed - indexed for MEDLINE]
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