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Cancer Metastasis Rev. 2009 Jun;28(1-2):247-63. doi: 10.1007/s10555-009-9186-7.

Osteosarcoma treatment: state of the art.

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  • 1Department of Chemical and Biomolecular Engineering, University of Melbourne, Melbourne, VIC, 3010, Australia.


Osteosarcoma (OS) is a class of cancer originating from bone, mainly afflicting children or young adults. It is the second highest cause of cancer-related death in these age groups, mainly due to development of often fatal metastasis, usually in the lungs. Survival for these patients is poor despite the aggressive use of surgery, chemotherapy, and/or radiotherapy. Thus, new effective drugs and other forms of therapy are needed. This article reviews the biology and the state of the art management of OS. New experimental drugs and potential therapies targeting molecular pathways of OS are also discussed.

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