Mol Cells. 2009 Jan 31;27(1):1-3. Epub 2009 Feb 5.

Mechanism, function and regulation of microtubule-dependent microtubule amplification in mitosis.

Source

Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.

Abstract

Mitotic spindle mediates the segregation of chromosomes in the cell cycle and the proper function of the spindle is crucial to the high fidelity of chromosome segregation and to the stability of the genome. Nucleation of microtubules (MTs) from centrosomes and chromatin represents two well-characterized pathways essential for the assembly of a dynamic spindle in mitosis. Recently, we identified a third MT nucleation pathway, in which existing MTs in the spindle act as a template to promote the nucleation and polymerization of MTs, thereby efficiently amplifying MTs in the spindle. We will review here our current understanding on the molecular mechanism, the physiological function and the cell-cycle regulation of MT amplification.

PMID:: 19214428; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Protein-Serine-Threonine Kinases

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. [J Cell Biol. 2008]
FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle.
Zhu H, Coppinger JA, Jang CY, Yates JR 3rd, Fang G. J Cell Biol. 2008 Dec 1; 183(5):835-48. Epub 2008 Nov 24.
Microtubule amplification in the assembly of mitotic spindle and the maturation of kinetochore fibers. [Commun Integr Biol. 2009]
Microtubule amplification in the assembly of mitotic spindle and the maturation of kinetochore fibers.
Zhu H, Fang K, Fang G. Commun Integr Biol. 2009 May; 2(3):208-10.
Microtubule cytoskeleton remodeling by acentriolar microtubule-organizing centers at the entry and exit from mitosis in Drosophila somatic cells. [Mol Biol Cell. 2009]
Microtubule cytoskeleton remodeling by acentriolar microtubule-organizing centers at the entry and exit from mitosis in Drosophila somatic cells.
Moutinho-Pereira S, Debec A, Maiato H. Mol Biol Cell. 2009 Jun; 20(11):2796-808. Epub 2009 Apr 15.
Review Mechanisms of mitotic spindle assembly and function. [Int Rev Cytol. 2008]
Review Mechanisms of mitotic spindle assembly and function.
Walczak CE, Heald R. Int Rev Cytol. 2008; 265:111-58.
Review Chromosome motors on the move. From motion to spindle checkpoint activity. [EMBO Rep. 2001]
Review Chromosome motors on the move. From motion to spindle checkpoint activity.
Brunet S, Vernos I. EMBO Rep. 2001 Aug; 2(8):669-73.

See reviews... See all...

Cited by 2 PubMed Central articles

Interactions between EB1 and microtubules: dramatic effect of affinity tags and evidence for cooperative behavior. [J Biol Chem. 2009]
Interactions between EB1 and microtubules: dramatic effect of affinity tags and evidence for cooperative behavior.
Zhu ZC, Gupta KK, Slabbekoorn AR, Paulson BA, Folker ES, Goodson HV. J Biol Chem. 2009 Nov 20; 284(47):32651-61. Epub 2009 Sep 23.
Lupeol triterpene, a novel diet-based microtubule targeting agent: disrupts survivin/cFLIP activation in prostate cancer cells. [Biochem Biophys Res Commun. 2009]
Lupeol triterpene, a novel diet-based microtubule targeting agent: disrupts survivin/cFLIP activation in prostate cancer cells.
Saleem M, Murtaza I, Witkowsky O, Kohl AM, Maddodi N. Biochem Biophys Res Commun. 2009 Oct 23; 388(3):576-82. Epub 2009 Aug 14.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Mechanism, function and regulation of microtubule-dependent microtubule amplific...
Mechanism, function and regulation of microtubule-dependent microtubule amplification in mitosis.
Mol Cells. 2009 Jan 31 ;27(1):1-3. Epub 2009 Feb 5 .

PubMed
Amorphous ferrous sulfide as a reducing agent for culture of anaerobes.
Amorphous ferrous sulfide as a reducing agent for culture of anaerobes.
Appl Environ Microbiol. 1977 Feb ;33(2):254-6.

PubMed
Mutagenic and genotoxic effects of cis-(dichloro)tetraammineruthenium(III) chlor...
Mutagenic and genotoxic effects of cis-(dichloro)tetraammineruthenium(III) chloride on human peripheral blood lymphocytes.
Biol Trace Elem Res. 2009 Sep ;130(3):249-61. Epub 2009 Feb 13 .

PubMed
Autistic enterocolitis: fact or fiction?
Autistic enterocolitis: fact or fiction?
Can J Gastroenterol. 2009 Feb ;23(2):95-8.

PubMed
Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: I.
Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: I.
J Ethnopharmacol. 1991 Jul ;33(3):263-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: