Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
N Engl J Med. 2009 Feb 12;360(7):692-8. doi: 10.1056/NEJMoa0802905.

Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation.

Author information

  • 1Department of Hematology, Oncology, and Transfusion Medicine, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Germany. gero.huetter@charite.de

Abstract

Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with acute myeloid leukemia and HIV-1 infection. The patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy. This outcome demonstrates the critical role CCR5 plays in maintaining HIV-1 infection.

2009 Massachusetts Medical Society

Comment in

PMID:
19213682
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Atypon Icon for Faculty of 1000
    Loading ...
    Write to the Help Desk