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Nat Rev Cancer. 2009 Mar;9(3):216-24. doi: 10.1038/nrc2591. Epub 2009 Feb 12.

Palindromic gene amplification--an evolutionarily conserved role for DNA inverted repeats in the genome.

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  • 1Department of Molecular Genetics, Cleveland Clinic Lerner Research Institute, 9,500 Euclid Avenue, Cleveland, Ohio 44195, USA. tanakah@ccf.org


The clinical importance of gene amplification in the diagnosis and treatment of cancer has been widely recognized, as it is often evident in advanced stages of diseases. However, our knowledge of the underlying mechanisms is still limited. Gene amplification is an essential process in several organisms including the ciliate Tetrahymena thermophila, in which the initiating mechanism has been well characterized. Lessons from such simple eukaryotes may provide useful information regarding how gene amplification occurs in tumour cells.

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