South Med J. 2009 Feb;102(2):216-8.

Bilateral Leser-Trélat sign mirroring lung adenocarcinoma with early metastases to the contralateral lung.

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Georgetown University, Washington, DC, USA. c_dasanu@yahoo.com

Abstract

We present a case featuring a unique overlap between the body areas involved by lung adenocarcinoma and the cutaneous paraneoplastic sign of Leser-Trélat. In our patient, the Leser-Trélat sign consisted of explosive multiple seborrheic keratoses in combination with acanthosis nigricans, representing a remarkable geometric skin projection of lung cancer which involved both the upper lobes. Our case suggests a unique interrelation between the paraneoplastic sign of Leser-Trélat and the tumor itself. The recognition of this phenomenon may contribute to an early diagnosis and prompt surgical treatment of occult cancers.

PMID:: 19209445; [PubMed - indexed for MEDLINE]

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The sign of Leser-Trélat in a case of adenocarcinoma of the lung. [J Am Acad Dermatol. 2000]
The sign of Leser-Trélat in a case of adenocarcinoma of the lung.
Heaphy MR Jr, Millns JL, Schroeter AL. J Am Acad Dermatol. 2000 Aug; 43(2 Pt 2):386-90.
[Acanthosis nigricans maligna and Leser-Trélat sign in double malignancy of the breast and stomach]. [Z Hautkr. 1987]
[Acanthosis nigricans maligna and Leser-Trélat sign in double malignancy of the breast and stomach].
Stieler W, Plewig G. Z Hautkr. 1987 Mar 1; 62(5):344-66.
Review Sign of Leser-Trélat. [J Am Acad Dermatol. 1996]
Review Sign of Leser-Trélat.
Schwartz RA. J Am Acad Dermatol. 1996 Jul; 35(1):88-95.
Review Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: a case report and literature review. [J Am Acad Dermatol. 2000]
Review Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: a case report and literature review.
Yeh JS, Munn SE, Plunkett TA, Harper PG, Hopster DJ, du Vivier AW. J Am Acad Dermatol. 2000 Feb; 42(2 Pt 2):357-62.
[Clinical and histopathological characteristics of early Leser-Trélat syndrome]. [Hautarzt. 2001]
[Clinical and histopathological characteristics of early Leser-Trélat syndrome].
Barth G, Basten O, Rüschoff J, Rompel R. Hautarzt. 2001 Jul; 52(7):649-52.

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