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    Chem Commun (Camb). 2009 Jan 21;(3):322-4. Epub 2008 Nov 20.

    Reversible molecular switching of molecular beacon: controlling DNA hybridization kinetics and thermodynamics using mercury(ii) ions.

    Yang R, Jin J, Long L, Wang Y, Wang H, Tan W.

    State Key Lab of Chemo/Biosensing and Chemometrics, Biomedical Engineering Center, College of Chemistry and Chemical Engineering, Hunan University, Changsa, 410082, China. Yangrh@pku.edu.cn

    We report that the hydrogen-bonding pattern in a molecular beacon can be replaced by metal-dependent pairs of Hg(2+) and DNA thymine (T) bases. A molecular beacon based on T-Hg(2+)-T exhibits a lower background signal and higher thermostability than regular molecular beacons.

    PMID: 19209316 [PubMed - indexed for MEDLINE]

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