Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Neurosci. 2009 Mar;10(3):199-210. doi: 10.1038/nrn2576. Epub 2009 Feb 11.

How (and why) the immune system makes us sleep.

Author information

  • 1Department of Human Physiology and Giuseppe Moruzzi Centre for Experimental Sleep Research, University of Milan Medical School, 20133 Milan, Italy.

Abstract

Good sleep is necessary for physical and mental health. For example, sleep loss impairs immune function, and sleep is altered during infection. Immune signalling molecules are present in the healthy brain, where they interact with neurochemical systems to contribute to the regulation of normal sleep. Animal studies have shown that interactions between immune signalling molecules (such as the cytokine interleukin 1) and brain neurochemical systems (such as the serotonin system) are amplified during infection, indicating that these interactions might underlie the changes in sleep that occur during infection. Why should the immune system cause us to sleep differently when we are sick? We propose that the alterations in sleep architecture during infection are exquisitely tailored to support the generation of fever, which in turn imparts survival value.

PMID:
19209176
[PubMed - indexed for MEDLINE]
PMCID:
PMC2839418
Free PMC Article

Images from this publication.See all images (5)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk