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ACS Nano. 2008 May;2(5):889-96.

Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery.

Liong M, Lu J, Kovochich M, Xia T, Ruehm SG, Nel AE, Tamanoi F, Zink JI.

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Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.

Abstract

Drug delivery, magnetic resonance and fluorescence imaging, magnetic manipulation, and cell targeting are simultaneously possible using a multifunctional mesoporous silica nanoparticle. Superparamagnetic iron oxide nanocrystals were encapsulated inside mesostructured silica spheres that were labeled with fluorescent dye molecules and coated with hydrophilic groups to prevent aggregation. Water-insoluble anticancer drugs were delivered into human cancer cells; surface conjugation with cancer-specific targeting agents increased the uptake into cancer cells relative to that in non-cancerous fibroblasts. The highly versatile multifunctional nanoparticles could potentially be used for simultaneous imaging and therapeutic applications.

PMID:: 19206485; [PubMed - indexed for MEDLINE]
PMCID:: PMC2751731

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