Your browser version may not work well with NCBI's Web applications. More information here...
1: J Neurosci Res. 1991 Jul;29(3):401-12.Links

Cloning of a human cDNA expressing a high voltage-activating, TEA-sensitive, type-A K+ channel which maps to chromosome 1 band p21.

Rudy B, Sen K, Vega-Saenz de Miera E, Lau D, Ried T, Ward DC.

Department of Physiology and Biophysics, New York University Medical Center, NY 10016.

Over ten different mammalian genes related to the Drosophila Shaker gene (the Sh gene family) have been identified recently. These genes encode subunits of voltage-dependent K+ channels. The family consists of four subfamilies: ShI genes are homologues of Shaker; ShII, ShIII, and ShIV are homologues of three other Shaker-like genes in Drosophila, Shab, Shaw, and Shal, respectively. We report here the cloning of a human K+ channel ShIII cDNA (HKShIIIC) obtained from a brain stem cDNA library. HKShIIIC transcripts express an atypical voltage-dependent transient (A-type) K+ current in Xenopus oocytes. This current is activated by large membrane depolarizations and is extremely sensitive to the K+ channel blocker TEA unlike most A-type currents. The gene encoding HKShIIIC maps to chromosome 1p21.

PMID: 1920536 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Potassium (Glu-K® , K+ 10® , K+ 8® , ...)

    Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually the food you eat supplies all of the potassium you need. However, certain diseases (e.g., kidney dis...

  • Source: AHFS Consumer Medication Information