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Arch Ophthalmol. 2009 Feb;127(2):132-40. doi: 10.1001/archophthalmol.2008.565.

Observational study of the development of diabetic macular edema following panretinal (scatter) photocoagulation given in 1 or 4 sittings.

Collaborators (297)

Browning D, Antoszyk AN, Brooks DR, Cowen MK, Stallings AH, Helms JV, Price AK, Murphy HL, Pierce RE, Ruiz KA, George RJ, McOwen MD, Balasubramaniam UM, Powers ME, McClain D, Clark LM, Davis LM, Braverman JM, Ciardella AP, Ryman LS, Dixon BF, Stillberger MA, Zapata JD, Rhodes RC, Brown DM, Elman MJ, Raden RZ, Sloan MD, Butcher TM, Starr J, Salfer-Firestone D, Coffey T, Singletary PV, Gore N, Cain T, Sotirakos P, Shabi G, Lazarus HS, Bunch DP, Ridge AD, Booth K, Davis LC, Trimble M, Moore J, Fish GE, Wang RC, Arnwine J, Arceneaux S, Sanchez B, Gray K, Cummings K, Aguado H, Jaramillo D, Gross JG, Fishburne BC, Magee MA, Flowers AM, Cummings PW, Gabriel RA, Bland KK, Lovit HK, Mallet CN, Price RL, Christoff R, Edwards PA, Ober MD, Rock SM, Monk MK, Murphy J, Wilson DF, Croswell M, Rusinek BA, Schillace LM, Troszak TA, Stern BA, Wells JA, Clark WL, Gridine MD, Cahill CP, Hickman AB, Spivey R, Kim JE, Han DP, Wirostko WJ, Alvarez D, Drescher TS, Knapp RJ, Barwick V, Flanders J, Backes DB, Selchert KJ, Beringer JR, Keller KL, Chan CK, Salib DM, Lin SG, Nuthi AS, Dickerson ED, Keith TL, Sage KE, Andresen TA, Aldana I, Wiskirchen TB, Castillo SU, Warren S, Rollins K, Huff KM, Chesbrough DJ, Bretz SE, Sharuk GS, Schlossman DK, Kopple A, Stockman ME, Cavicchi RW, Casazza EL, Fan JT, Rauser ME, Rollins KE, Corliss CJ, Osuna SL, Kiernan WH, Cloud JD, Milam W, Saldana G, Hampton GR, Spalding SC, Torrisi PF, Rutledge BK, Grinnell CJ, DiSano FM, Kwasniewski LM, Czajak TC, Capone LA, Corey B, Hay PB, Martinez JA, Montesclaros CA, Odean CE, Sabo RA, Garcia CA, McCrary J, Garibay E, Lessieur EM, Villeda PR, Paz HL, Montoya JP, Nguyen CV, Santisbon E, Cerda SM, Lopez RA, Ramirez A, Friedman SM, Blackmer KA, Key JS, Carlton S, Fagan DA, Gregory V, Aaberg TM, Scott S, Markus D, Kronlein S, Lewis S, Shami M, Pusser P, Tarter CL, Squires L, Wentlandt TF, Hartnett ME, Garg S, Barnhart CJ, Cantrell D, Esquejo RL, Shields KD, Lyon AT, Kaminski LA, Ackatz LE, O'Donnell LM, Shankle J, Davidorf FH, Green AM, Perry JG, Chaudhuri CG, Savage SJ, Drouilhet JH, Pelke S, Nobler D, Batlle IR, Batlle KA, Williams GM, Parks M, Googe J, McMillan TA, Anderson NG, Perkins SL, Higdon CT, Hunt C, Whetstone JK, Jacobus M, Moore M, Blais PA, Cooney MJ, Sorenson JA, Maranan L, Sco M, Agresta EI, Smith CW, DuCoty CL, Varadian S, Salinas C, Banalewicz E, Hamel M, Nagle AL, Chen M, Wong KL, Holland C, Hagin K, Sneath M, Miller R, Beck RW, Glassman AR, Barros J, Dale BB, Constantine SR, Dupre SS, Edwards AR, Hutton M, Johnson PA, Kollman C, Lester LA, Loggins BL, McClellan SL, Murtaugh P, Moke PS, Qin H, Pritchard R, Ramirez H, Scott E, Stockdale CR, Davis MD, Danis RP, Hubbard L, Reimers J, Vargo P, Moeller E, Myers D, Daywalt M, Bressler NM, Aiello LP, Everett DF, Miskala PH, Brucker AJ, Browning D, Chew EY, Danis RP, Haller JA, Aiello LP, Baker CW, Bressler NM, Bunch DP, Everett DF, Ferris F, Glassman AR, Marcus DM, Anderson G, Carlton S, Gardner T, Gross JG, Li HK, Price AK, Miskala P, Fong DS, Bressler NM, Aiello LP, Beck RW, Bhavsar A, Danis RP, Davis MD, Everett DF, Ferris FL, Fish J, Friedman S, Glassman AR, Lauer A, Brown DM, Browning DJ, Elman MJ, McLead K, Miskala PH, Grinnell CJ, Connett J, Barnbaum D, Flynn HW Jr, Frank RN, Genuth S, Jampol L, Wisniewski S, Resnick J.

Abstract

OBJECTIVE:

To compare the effects of single-sitting vs 4-sitting panretinal photocoagulation (PRP) on macular edema in subjects with severe nonproliferative or early proliferative diabetic retinopathy with relatively good visual acuity and no or mild center-involved macular edema.

METHODS:

Subjects were treated with 1 sitting or 4 sittings of PRP in a nonrandomized, prospective, multicentered clinical trial. Main Outcome Measure Central subfield thickness on optical coherence tomography (OCT).

RESULTS:

Central subfield thickness was slightly greater in the 1-sitting group (n = 84) than in the 4-sitting group (n = 71) at the 3-day (P = .01) and 4-week visits (P = .003). At the 34-week primary outcome visit, the slight differences had reversed, with the thickness being slightly greater in the 4-sitting group than in the 1-sitting group (P = .06). Visual acuity differences paralleled OCT differences.

CONCLUSIONS:

Our results suggest that clinically meaningful differences are unlikely in OCT thickness or visual acuity following application of PRP in 1 sitting compared with 4 sittings in subjects in this cohort. More definitive results would require a large randomized trial. Application to Clinical Practice These results suggest PRP costs to some patients in terms of travel and lost productivity as well as to eye care providers could be reduced.

TRIAL REGISTRATION:

clinicaltrials.gov Identifier: NCT00687154.

Comment in

PMID:
19204228
[PubMed - indexed for MEDLINE]
PMCID:
PMC2754061
Free PMC Article

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