Abstract
Five new benzophenone derivatives, 13,14-didehydoxyisogarcinol (1), garcimultiflorone A (2), garcimultiflorone B (3), 13-hydroxygarcimultiflorone B (4), and garcimultiflorone C (5), have been isolated from the fruits of Garcinia multiflora, together with seven known compounds (6-12). The structures of these new compounds were determined through spectroscopic and MS analyses. 13,14-Didehydoxyisogarcinol (1), garcimultiflorone A (2), garcimultiflorone B (3), and 13-hydroxygarcimultiflorone B (4) exhibited inhibition with an IC(50) range of 0.11-5.58 microM on superoxide anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B (fMLP/CB).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Benzophenones / chemistry
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Benzophenones / isolation & purification*
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Benzophenones / pharmacology*
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Cytochalasin B / pharmacology
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Fruit / chemistry
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Garcinia / chemistry*
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Humans
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Molecular Structure
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Neutrophils / drug effects
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Neutrophils / enzymology
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Nuclear Magnetic Resonance, Biomolecular
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Pancreatic Elastase / antagonists & inhibitors
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Pancreatic Elastase / drug effects*
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Plants, Medicinal / chemistry*
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Superoxides / analysis
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Benzophenones
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Superoxides
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Cytochalasin B
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Pancreatic Elastase