Benzophenone derivatives from the fruits of Garcinia multiflora and their anti-inflammatory activity

J Nat Prod. 2009 Feb 27;72(2):253-8. doi: 10.1021/np8006364.

Abstract

Five new benzophenone derivatives, 13,14-didehydoxyisogarcinol (1), garcimultiflorone A (2), garcimultiflorone B (3), 13-hydroxygarcimultiflorone B (4), and garcimultiflorone C (5), have been isolated from the fruits of Garcinia multiflora, together with seven known compounds (6-12). The structures of these new compounds were determined through spectroscopic and MS analyses. 13,14-Didehydoxyisogarcinol (1), garcimultiflorone A (2), garcimultiflorone B (3), and 13-hydroxygarcimultiflorone B (4) exhibited inhibition with an IC(50) range of 0.11-5.58 microM on superoxide anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B (fMLP/CB).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Benzophenones / chemistry
  • Benzophenones / isolation & purification*
  • Benzophenones / pharmacology*
  • Cytochalasin B / pharmacology
  • Fruit / chemistry
  • Garcinia / chemistry*
  • Humans
  • Molecular Structure
  • Neutrophils / drug effects
  • Neutrophils / enzymology
  • Nuclear Magnetic Resonance, Biomolecular
  • Pancreatic Elastase / antagonists & inhibitors
  • Pancreatic Elastase / drug effects*
  • Plants, Medicinal / chemistry*
  • Superoxides / analysis

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Benzophenones
  • Superoxides
  • Cytochalasin B
  • Pancreatic Elastase