Hum Vaccin. 2009 Apr;5(4):264-7. Epub 2009 Apr 30.

Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins.

Source

Equipe Interactions des bactéries commensales et probiotiques avec l'hôte, Unité d'Ecologie et physiologie du Système Digestif, INRA 0910, Jouy-en-Josas, France. luis.bermudez@jouy.inra.fr

Abstract

Food-grade lactic acid bacteria (LAB) have been safely consumed by humans for centuries in fermented foods. Lactococcus lactis, a LAB widely used in the dairy industry as a starter, can be genetically engineered to efficiently produce a large variety of proteins. This feature has been recently exploited by scientists for the development of a new generation of vectors to deliver therapeutic proteins to the mucosal tissues. The successful Phase I clinical trial with a L. lactis strain secreting interleukin-10 for Crohn's disease has opened new horizons for the use of genetically engineered LAB as delivery vehicles. This commentary reviews the current advances made with L. lactis as live vector for the mucosal delivery of therapeutic proteins.

PMID:: 19202351; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Landes Bioscience

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Transgenic probiotica as drug delivery systems: the golden bullet? [Expert Opin Drug Deliv. 2007]
Transgenic probiotica as drug delivery systems: the golden bullet?
Yuvaraj S, Peppelenbosch MP, Bos NA. Expert Opin Drug Deliv. 2007 Jan; 4(1):1-3.
Review Heterologous protein production and delivery systems for Lactococcus lactis. [Genet Mol Res. 2003]
Review Heterologous protein production and delivery systems for Lactococcus lactis.
Nouaille S, Ribeiro LA, Miyoshi A, Pontes D, Le Loir Y, Oliveira SC, Langella P, Azevedo V. Genet Mol Res. 2003 Mar 31; 2(1):102-11. Epub 2003 Mar 31.
Review Lactococcus lactis as a cell factory for delivery of therapeutic proteins. [Curr Gene Ther. 2010]
Review Lactococcus lactis as a cell factory for delivery of therapeutic proteins.
Bahey-El-Din M, Gahan CG, Griffin BT. Curr Gene Ther. 2010 Feb; 10(1):34-45.
Review Modulation of gut-associated lymphoid tissue functions with genetically modified Lactococcus lactis. [Int Rev Immunol. 2009]
Review Modulation of gut-associated lymphoid tissue functions with genetically modified Lactococcus lactis.
Rottiers P, De Smedt T, Steidler L. Int Rev Immunol. 2009; 28(6):465-86.
Review Current prophylactic and therapeutic uses of a recombinant Lactococcus lactis strain secreting biologically active interleukin-12. [J Mol Microbiol Biotechnol. 2008]
Review Current prophylactic and therapeutic uses of a recombinant Lactococcus lactis strain secreting biologically active interleukin-12.
Bermúdez-Humarán LG, Cortes-Perez NG, Ah-Leung S, Lefèvre F, Yang G, Pang Q, Wu C, Zeng Y, Adel-Patient K, Langella P. J Mol Microbiol Biotechnol. 2008; 14(1-3):80-9.

See reviews... See all...

Cited by 3 PubMed Central articles

Review Lactococci and lactobacilli as mucosal delivery vectors for therapeutic proteins and DNA vaccines. [Microb Cell Fact. 2011]
Review Lactococci and lactobacilli as mucosal delivery vectors for therapeutic proteins and DNA vaccines.
Bermúdez-Humarán LG, Kharrat P, Chatel JM, Langella P. Microb Cell Fact. 2011 Aug 30; 10 Suppl 1:S4. Epub 2011 Aug 30.
Engineering trehalose synthesis in Lactococcus lactis for improved stress tolerance. [Appl Environ Microbiol. 2011]
Engineering trehalose synthesis in Lactococcus lactis for improved stress tolerance.
Carvalho AL, Cardoso FS, Bohn A, Neves AR, Santos H. Appl Environ Microbiol. 2011 Jun; 77(12):4189-99. Epub 2011 Apr 22.
Multi-omics approach to study the growth efficiency and amino acid metabolism in Lactococcus lactis at various specific growth rates. [Microb Cell Fact. 2011]
Multi-omics approach to study the growth efficiency and amino acid metabolism in Lactococcus lactis at various specific growth rates.
Lahtvee PJ, Adamberg K, Arike L, Nahku R, Aller K, Vilu R. Microb Cell Fact. 2011 Feb 24; 10:12. Epub 2011 Feb 24.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins...
Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins.
Hum Vaccin. 2009 Apr ;5(4):264-7. Epub 2009 Apr 30 .

PubMed
The evolutionary theories of aging revisited--a mini-review.
The evolutionary theories of aging revisited--a mini-review.
Gerontology. 2009 ;55(2):205-16. Epub 2009 Feb 7 .

PubMed
Healthy Colon, Healthy Life (Ruot Lành, Song Khoe): patient and physician factor...
Healthy Colon, Healthy Life (Ruot Lành, Song Khoe): patient and physician factors associated with colorectal cancer screening among Vietnamese Americans in a county medical care system.
J Health Care Poor Underserved. 2009 Feb ;20(1):74-89.

PubMed
Clinical variants of Guillain-Barre syndrome: some aspects of differential diagn...
Clinical variants of Guillain-Barre syndrome: some aspects of differential diagnosis.
Georgian Med News. 2009 Jan ;(166):48-51.

PubMed
Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ov...
Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis.
Proc Natl Acad Sci U S A. 2009 Feb 24 ;106(8):2806-11. Epub 2009 Feb 6 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: