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Biosci Biotechnol Biochem. 2009 Feb;73(2):431-3. Epub 2009 Feb 7.

Effects of long-term administration of royal jelly on pituitary weight and gene expression in middle-aged female rats.

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  • 1Nagaragawa Research Center, API Co., Ltd., Nagara, Gifu, Japan.


To determine the effects of ingested royal jelly (RJ) on the pituitary in middle-aged female rats, we performed a long-term RJ administration test. Several animals showed age-related increases in pituitary weight, and RJ administration compensated for the increase. RJ tended to down-regulate prolactin mRNA and up-regulated thyroid-stimulating hormone beta mRNA in the pituitary. This suggests that RJ compensates for age-associated decline in pituitary functions.

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