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J Immunol. 2009 Feb 15;182(4):1794-8. doi: 10.4049/jimmunol.0801347.

Cutting edge: Phenotypic characterization and differentiation of human CD8+ T cells producing IL-17.

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  • 1Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan.

Abstract

Although IL-17-producing CD8(+) T cells (Tc17 cells) have recently been identified, the detailed information about these cells still remains unclear. In this article we describe a study investigating the phenotype and differentiation of human Tc17 cells. Human Tc17 cells were detected in a minor population of CD8(+) T cells and were predominantly found in CD27(-/+)CD28(+)CD45RA(-) memory subsets. They also expressed CCR6 and a high level of CCR5. Though most Tc17 cells produced IFN-gamma, a small part of the Tc17 cell population was IFN-gamma negative in some individuals. Analysis of the in vitro induction of Tc17 cells showed that these cells were induced from the CD27(+)CD28(+)CD45RA(+) naive subset and that they expressed the CD27(-)CD28(+)CD45RA(-) and CCR6(+) phenotype. These results together indicate that Tc17 cells have a unique phenotype and suggest that they differentiate from the same precursors that differentiate into IFN-gamma-producing CD8(+) T cells.

PMID:
19201830
[PubMed - indexed for MEDLINE]
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