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    Anticancer Agents Med Chem. 2009 Feb;9(2):138-61.

    Quercetin and its derivatives: synthesis, pharmacological uses with special emphasis on anti-tumor properties and prodrug with enhanced bio-availability.

    Hirpara KV, Aggarwal P, Mukherjee AJ, Joshi N, Burman AC.

    Source

    Chemical Research, Dabur Research Foundation, Ghaziabad, U.P. India. ketanvh@dabur.com

    Abstract

    Cancer is one of the leading causes of death in the world. American Cancer Society reported 12 million new cases of malignancy diagnosed worldwide in 2007, with 7.6 million people dying from the disease. Plant-derived molecules have played an important role in cancer chemotherapy. Many cytotoxic plant-derived molecules such as vinblastine, vincristine, navelbine, etoposide, teniposide, taxol, taxotere, topotecan and irinotecan have been approved as anticancer drugs. Flavonoids, a plant-derived molecule has shown to regulate proliferation and cell death pathways leading to cancer. Some Flavonoids have already entered in clinical trials, among them Quercetin is emerging as prospective anticancer drug candidates and its prodrug QC12 has entered in phase-I clinical studies. In this review authors have tried to cover in brief but comprehensive way, the chemistry related to synthesis and uses of "Quercetin & its derivatives" with special emphasis on the anticancer properties.

    PMID:
    19199862
    [PubMed - indexed for MEDLINE]

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