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Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Feb;26(1):95-7. doi: 10.3760/cma.j.issn.1003-9406.2009.01.022.

[The investigation of the relationship between the phenotypes of 46, XX males and the SRY gene].

[Article in Chinese]

Author information

  • 1Genetics Laboratory, the Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning, 110004 PR China. wangyueping12@tom.com

Abstract

OBJECTIVE:

To investigate the relationship between the phenotypes in XX male patients and the sex determining region(SRY) gene.

METHODS:

Multiple polymerase chain reactions were carried out in 6 male patients with karyotype of 46, XX, and then the PCR products were sequenced directly.

RESULTS:

Three cases of male infertility were positive for the SRY gene without evident malformation in their extra genitalia, while 3 cases with testes were negative for the SRY gene, with evident malformation in their extra genitalia.

CONCLUSION:

The SRY gene is key in sex determination and development, yet there might be other important genes involved.

[PubMed - indexed for MEDLINE]
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