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Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Feb;26(1):95-7. doi: 10.3760/cma.j.issn.1003-9406.2009.01.022.

[The investigation of the relationship between the phenotypes of 46, XX males and the SRY gene].

[Article in Chinese]

Author information

  • 1Genetics Laboratory, the Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning, 110004 PR China.



To investigate the relationship between the phenotypes in XX male patients and the sex determining region(SRY) gene.


Multiple polymerase chain reactions were carried out in 6 male patients with karyotype of 46, XX, and then the PCR products were sequenced directly.


Three cases of male infertility were positive for the SRY gene without evident malformation in their extra genitalia, while 3 cases with testes were negative for the SRY gene, with evident malformation in their extra genitalia.


The SRY gene is key in sex determination and development, yet there might be other important genes involved.

[PubMed - indexed for MEDLINE]
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