Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2009 Feb 6;323(5915):779-82. doi: 10.1126/science.1169123.

Evolution of the Drosophila nuclear pore complex results in multiple hybrid incompatibilities.

Author information

  • 1Department of Biology, University of Rochester, Rochester, NY 14627, USA.

Abstract

Speciation often involves the evolution of incompatible gene interactions that cause sterility or lethality in hybrids between populations. These so-called hybrid incompatibilities occur between two or more functionally divergent loci. We show that the nucleoporin 160kDa (Nup160) gene of the fruitfly Drosophila simulans is incompatible with one or more factors on the D. melanogaster X chromosome, causing hybrid lethality. Nup160 encodes a nuclear pore complex protein and shows evidence of adaptive evolution. Furthermore, the protein encoded by Nup160 directly interacts with that of another hybrid lethality gene, Nup96, indicating that at least two lethal hybrid incompatibility genes have evolved as byproducts of divergent coevolution among interacting components of the Drosophila nuclear pore complex.

PMID:
19197064
[PubMed - indexed for MEDLINE]
PMCID:
PMC2826207
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk