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J Neuropsychiatry Clin Neurosci. 2008 Fall;20(4):450-7. doi: 10.1176/appi.neuropsych.20.4.450.

Long-term follow-up study of patients with refractory obsessive-compulsive disorder.

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  • 1Department of Adult Psychiatry, New York University, NY, USA.


The authors prospectively followed patients with treatment-resistant obsessive-compulsive disorder (OCD). Between 1988 and 1995, 56 patients with a history of inadequate response to oral clomipramine received 14 infusions of intravenous clomipramine. The follow-up period ranged from 4 to 11 years after treatment. Of the 44 subjects interviewed at follow-up, 70.5% had current OCD and 29.5% had sub-threshold OCD. Almost half reported feeling much improved or very much improved compared to their state prior to treatment with intravenous clomipramine.

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