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    J Neuropsychiatry Clin Neurosci. 2008 Fall;20(4):419-30.

    Neural correlates of automatic and controlled auditory processing in schizophrenia.

    Morey RA, Mitchell TV, Inan S, Lieberman JA, Belger A.

    Source

    Duke-UNC Brain Imaging and Analysis Center, Department of Psychiatry, Duke University, Box 3918, Durham, NC 27707, USA. morey@biac.duke.edu

    Abstract

    Individuals with schizophrenia demonstrate impairments in selective attention and sensory processing. The authors assessed differences in brain function between 26 participants with schizophrenia and 17 comparison subjects engaged in automatic (unattended) and controlled (attended) auditory information processing using event-related functional MRI. Lower regional neural activation during automatic auditory processing in the schizophrenia group was not confined to just the temporal lobe, but also extended to prefrontal regions. Controlled auditory processing was associated with a distributed frontotemporal and subcortical dysfunction. Differences in activation between these two modes of auditory information processing were more pronounced in the comparison group than in the patient group.

    PMID:
    19196926
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2709774
    Free PMC Article

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