OBJECTIVE: To determine the net financial gain or loss for herpes zoster vaccination services provided to patients from the perspective of an independent community pharmacy. DESIGN: Retrospective review of pharmacy records over the program's initial 11-month period. SETTING: Independent community pharmacy in Iowa City, IA. PARTICIPANTS: Patients received immunization with the herpes zoster vaccine from a certified pharmacist. INTERVENTION: Herpes zoster vaccination services were provided to the patient and documented by the pharmacist. MAIN OUTCOME MEASURE: Net financial gains or losses were calculated for the herpes zoster vaccination program. Sensitivity analyses were based on costs that might be incurred during program start-up. RESULTS: 478 patients received zoster vaccination services over the initial 11-month period. A net financial gain for the herpes zoster vaccination program was achieved, with a net profit of $15.02, or 8.15%, per vaccination. CONCLUSION: Revenues for this vaccination program exceeded its costs from the independent community pharmacy perspective.