Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Cell Biol. 2009 Feb;21(1):14-9. doi: 10.1016/ Epub 2009 Feb 3.

Centriole evolution.

Author information

  • 1Dept. of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.


Centrioles are cylindrical structures found at the core of the mitotic spindle pole, which also act as basal bodies to nucleate the formation of cilia. Centrioles have a complex, ninefold symmetric structure, and reproduce by an intriguing duplication process. The complexity and apparent self-reproduction of centrioles raises the question of how such a structure could have evolved, making them a favorite topic for theological speculation by 'intelligent design' creationists. In fact, centrioles are capable of robust self-assembly and can tolerate dramatic perturbations while still maintaining basic functionality. Far from being irreducibly complex, centrioles appear to be based on a rather minimal underlying core structure requiring only a handful of genes to construct.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk