[Clinical data II. Clinical experience of tenofovir DF in combination with protease inhibitors]

Enferm Infecc Microbiol Clin. 2008 Jun:26 Suppl 8:13-8. doi: 10.1157/13126267.
[Article in Spanish]

Abstract

Tenofovir is one of the drugs of choice in first-line combinations of antiretroviral therapy. Most data on safety and efficacy in this scenario initially came from clinical trials in which tenofovir was combined with non-nucleoside reverse transcriptase inhibitors. Because of this, as well as the possible interaction of tenofovir with some protease inhibitors and the suspicion that this combination could increase the risk of nephrotoxicity, analysis of the clinical experience available on the combination of tenofovir (associated with emtricitabine or another nucleoside analogue) with a protease inhibitor is essential. The present review reports data on efficacy and safety, mainly from clinical trials. Taken together, these studies provide sufficient information to indicate that the combination of tenofovir and protease inhibitors is safe and effective, justifying its selection in first-line therapy or rescue therapy after virological failure.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Adenine / administration & dosage
  • Adenine / adverse effects
  • Adenine / analogs & derivatives*
  • Adenine / pharmacology
  • Adenine / therapeutic use
  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / classification
  • Anti-HIV Agents / pharmacology
  • Anti-HIV Agents / therapeutic use*
  • Antiretroviral Therapy, Highly Active
  • Clinical Trials as Topic / statistics & numerical data
  • Cohort Studies
  • Deoxycytidine / administration & dosage
  • Deoxycytidine / adverse effects
  • Deoxycytidine / analogs & derivatives
  • Deoxycytidine / therapeutic use
  • Diabetic Nephropathies / complications
  • Double-Blind Method
  • Drug Resistance, Multiple, Viral / genetics
  • Drug Therapy, Combination
  • Emtricitabine
  • HIV / drug effects*
  • HIV / enzymology
  • HIV / genetics
  • HIV Infections / drug therapy*
  • HIV Protease Inhibitors / administration & dosage
  • HIV Protease Inhibitors / adverse effects
  • HIV Protease Inhibitors / therapeutic use*
  • HIV Reverse Transcriptase / antagonists & inhibitors
  • HIV Reverse Transcriptase / genetics
  • Humans
  • Kidney Diseases / chemically induced
  • Multicenter Studies as Topic
  • Organophosphonates / administration & dosage
  • Organophosphonates / adverse effects
  • Organophosphonates / pharmacology
  • Organophosphonates / therapeutic use*
  • Randomized Controlled Trials as Topic / statistics & numerical data
  • Retrospective Studies
  • Reverse Transcriptase Inhibitors / administration & dosage
  • Reverse Transcriptase Inhibitors / adverse effects
  • Reverse Transcriptase Inhibitors / pharmacology
  • Reverse Transcriptase Inhibitors / therapeutic use*
  • Salvage Therapy
  • Tenofovir
  • Treatment Outcome

Substances

  • Anti-HIV Agents
  • HIV Protease Inhibitors
  • Organophosphonates
  • Reverse Transcriptase Inhibitors
  • Deoxycytidine
  • Tenofovir
  • HIV Reverse Transcriptase
  • Emtricitabine
  • Adenine