Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Korean Med Sci. 2009 Jan;24 Suppl:S210-4. doi: 10.3346/jkms.2009.24.S1.S210. Epub 2009 Jan 28.

Two Korean infants with genetically confirmed congenital nephrotic syndrome of Finnish type.

Author information

  • 1Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.

Abstract

Congenital nephrotic syndrome is defined as nephrotic syndrome which manifests in utero or during the first 3 months of life. The prototype of congenital nephrotic syndrome is congenital nephrotic syndrome of Finnish type (CNF, OMIM #602716), which is caused by loss-of-function mutations of the nephrin gene (NPHS1). There have been few clinical case reports of CNF in Korea, but none of which was confirmed by genetic study. Here, we report two children with congenital nephrotic syndrome. Genetic analysis of the NPHS1 gene revealed compound heterozygous frame-shifting mutations (c.2156_2163 delTGCACTGC causing p.L719DfsX4 and c.3250_3251insG causing p.V1084GfsX12) in one patient and a missense mutation (c.1381G>A causing p.R460Q) and a nonsense mutation (c.2442C>G causing p.Y814X) in the other patient. The nonsense mutation was novel. The clinical courses of the patients were typical of CNF. This is the first report of genetically confirmed CNF in Korea to date. The early genetic diagnosis of CNF is important for proper clinical management of the patients and precise genetic counseling of the families.

KEYWORDS:

Congenital Nephrotic Syndrome; Congenital Nephrotic Syndrome of Finnish Type; Mutation; NPHS1 Gene; Nephrin

PMID:
19194555
[PubMed - indexed for MEDLINE]
PMCID:
PMC2633182
Free PMC Article

Images from this publication.See all images (3)Free text

Fig. 1
Fig. 2
Fig. 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Korean Academy of Medical Sciences Icon for PubMed Central
    Loading ...
    Write to the Help Desk