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Urology. 2009 Apr;73(4):706-9. doi: 10.1016/j.urology.2008.11.013. Epub 2009 Feb 4.

Prospective randomized trial comparing efficacy of alfuzosin and tamsulosin in management of lower ureteral stones.

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  • 1Division of Urology, Department of Surgery, S N Medical College, Agra, India. dr.madhu.agra@gmail.com

Abstract

OBJECTIVES:

To study the efficacy of alfuzosin compared with tamsulosin in the management of lower ureteral stones.

METHODS:

A total of 102 patients with stones <1 cm size and located in the lower ureter were enrolled in the present study and randomized into 3 equal groups. Group 1 patients (n = 34) received 0.4 mg tamsulosin daily, group 2 patients (n = 34) received 10 mg alfuzosin daily, and group 3 patients (n = 34) received placebo (control group). The patients were given 75 mg diclofenac injection intramuscularly on demand and were followed up for 4 weeks.

RESULTS:

The average stone size for groups 1, 2, and 3 was comparable (6.17, 6.70, and 6.35 mm, respectively). Stone expulsion was observed in 28 of 34 patients (82.3%) in group 1, 24 of 34 patients (70.5%) in group 2, and 12 of 34 patients (35.2%) in group 3. The average expulsion time for groups 1, 2, and 3 was 12.3, 14.5, and 24.5 days, respectively. The results of both study groups (groups 1 and 2) were superior to those in the placebo group (P = .003 and P = .001, respectively), but the study failed to show any statistically significant differences between tamsulosin and alfuzosin (P = .25). Alfuzosin was associated with fewer side effects than tamsulosin, especially in terms of retrograde ejaculation.

CONCLUSIONS:

Medical treatment of lower ureteral calculi with tamsulosin and alfuzosin resulted in a significantly increased stone expulsion rate, decreased expulsion time, and a reduced need for analgesic therapy.

PMID:
19193417
[PubMed - indexed for MEDLINE]
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