Oral Dis. 2008 Nov;14(8):673-82.

Genetic contributions to pain: a review of findings in humans.

Fillingim RB, Wallace MR, Herbstman DM, Ribeiro-Dasilva M, Staud R.

Source

College of Dentistry, University of Florida, Gainesville, FL 32608, USA. rfilling@ufl.edu

Abstract

Pain represents the major motivating factor for which individuals seek healthcare, and pain responses are characterized by substantial inter-individual differences. Increasing evidence suggests that genetic factors contribute significantly to individual differences in responses to both clinical and experimental pain. The purpose of this review article was to summarize the current literature regarding genetic contributions to pain, highlighting findings relevant to oral pain where available. A brief discussion of methodologic considerations is followed by a review of findings regarding genetic influences on clinical pain. Next, the literature examining genetic contributions to experimental pain responses is presented, emphasizing genetic associations that have been replicated in multiple cohorts. It is hoped that an enhanced understanding of genetic contributions to pain responses will ultimately improve diagnosis and treatment of clinical pain conditions.

PMID:: 19193196; [PubMed - indexed for MEDLINE]
PMCID:: PMC2667226

Free PMC Article

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Pain - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Final Report on Carcinogens Background Document for Formaldehyde. [Rep Carcinog Backgr Doc. 2010]
Final Report on Carcinogens Background Document for Formaldehyde.
National Toxicology Program. Rep Carcinog Backgr Doc. 2010 Jan; (10-5981):i-512.
Review Genetic predictors of acute and chronic pain. [Curr Rheumatol Rep. 2006]
Review Genetic predictors of acute and chronic pain.
Edwards RR. Curr Rheumatol Rep. 2006 Dec; 8(6):411-7.
Are post-traumatic stress disorder symptoms and temporomandibular pain associated? Findings from a community-based twin registry. [J Orofac Pain. 2008]
Are post-traumatic stress disorder symptoms and temporomandibular pain associated? Findings from a community-based twin registry.
Afari N, Wen Y, Buchwald D, Goldberg J, Plesh O. J Orofac Pain. 2008 Winter; 22(1):41-9.
Review Genetic contributions to clinical pain and analgesia: avoiding pitfalls in genetic research. [J Pain. 2009]
Review Genetic contributions to clinical pain and analgesia: avoiding pitfalls in genetic research.
Kim H, Clark D, Dionne RA. J Pain. 2009 Jul; 10(7):663-93.
Heritability of responses to painful stimuli in women: a classical twin study. [Brain. 2007]
Heritability of responses to painful stimuli in women: a classical twin study.
Norbury TA, MacGregor AJ, Urwin J, Spector TD, McMahon SB. Brain. 2007 Nov; 130(Pt 11):3041-9. Epub 2007 Oct 11.

See reviews... See all...

Cited by 4 PubMed Central articles

The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status. [PLoS One. 2010]
The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status.
Vossen H, Kenis G, Rutten B, van Os J, Hermens H, Lousberg R. PLoS One. 2010 Oct 26; 5(10):e13641. Epub 2010 Oct 26.
Risk factors predicting the development of widespread pain from chronic back or neck pain. [J Pain. 2010]
Risk factors predicting the development of widespread pain from chronic back or neck pain.
Kindler LL, Jones KD, Perrin N, Bennett RM. J Pain. 2010 Dec; 11(12):1320-8. Epub 2010 May 21.
Smoking status and pain level among head and neck cancer patients. [J Pain. 2010]
Smoking status and pain level among head and neck cancer patients.
Logan HL, Fillingim RB, Bartoshuk LM, Sandow P, Tomar SL, Werning JW, Mendenhall WM. J Pain. 2010 Jun; 11(6):528-34. Epub 2009 Dec 16.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
SNP (Cited)
Nucleotide polymorphism records from dbSNP that have NCBI dbSNP identifiers reported in the PubMed abstract of the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
SNP
Nucleotide polymorphism records from dbSNP that have current articles as submitter-provided references.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Genetic contributions to pain: a review of findings in humans.
Genetic contributions to pain: a review of findings in humans.
Oral Dis. 2008 Nov ;14(8):673-82.

PubMed
GADEM: a genetic algorithm guided formation of spaced dyads coupled with an EM a...
GADEM: a genetic algorithm guided formation of spaced dyads coupled with an EM algorithm for motif discovery.
J Comput Biol. 2009 Feb ;16(2):317-29.

PubMed
Metabolic flux correlations, genetic interactions, and disease.
Metabolic flux correlations, genetic interactions, and disease.
J Comput Biol. 2009 Feb ;16(2):291-302.

PubMed
HIV preexposure prophylaxis in the United States: impact on lifetime infection r...
HIV preexposure prophylaxis in the United States: impact on lifetime infection risk, clinical outcomes, and cost-effectiveness.
Clin Infect Dis. 2009 Mar 15 ;48(6):806-15.

PubMed
Harvey Cushing's circus friend, the "world's ugliest woman".
Harvey Cushing's circus friend, the "world's ugliest woman".
J Lab Clin Med. 1991 Sep ;118(3):297-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: