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J Pediatr Endocrinol Metab. 2008 Dec;21(12):1113-8.

The diagnostic value of a brief GnRH analogue stimulation test in girls with central precocious puberty: a single 30-minute post-stimulation LH sample is adequate.

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  • 1Department of Pediatrics, Backus Children's Hospital, Mercer University School of Medicine, Savannah, GA, USA.


To ascertain the diagnostic value of GnRHa stimulation testing in girls with CPP, single sample 30 minute post-stimulated gonadotropin levels were compared between girls with CPP and prepubertal girls. Serum LH and FSH concentrations were assayed using two third generation gonadotropin assays. Clinical data were reviewed to establish the diagnosis of CPP. GnRHa stimulation testing with one LH measurement obtained 30 minutes after stimulation is adequate for evaluating girls with CPP and as reliable as GnRH stimulation testing.

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