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J Clin Immunol. 2009 May;29(3):311-8. doi: 10.1007/s10875-009-9275-y. Epub 2009 Feb 3.

CD8+ cell anti-HIV activity rapidly increases upon discontinuation of early antiretroviral therapy.

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  • 1Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.

Abstract

INTRODUCTION:

CD8+ lymphocytes can suppress HIV replication without killing the infected cells. This CD8+ cell noncytotoxic anti-HIV response (CNAR) is associated with a beneficial clinical course.

MATERIALS AND METHODS:

In this longitudinal study of 16 participants in the Options Project at UCSF, we measured the ability of CD8+ lymphocytes to suppress HIV replication in CD4+ cells during primary HIV infection, early antiretroviral therapy, and after treatment.

RESULTS AND DISCUSSION:

CD8+ lymphocytes from subjects with untreated primary HIV-1 infection strongly suppressed HIV replication. Initiation of antiretroviral therapy during primary HIV-1 infection caused a marked decline in this CNAR. CD8+ cells from these subjects regained anti-HIV activity when early therapy was discontinued. The timing of the appearance of CD8+ cell anti-HIV activity directly correlated with the emergence of detectable virus levels. Maximal CNAR activity coincided with a decay in the kinetics of HIV replication. In addition, peak viral loads during treatment interruption were lower than pre-treatment virus levels (median reduction = 0.8 logs, p = 0.005) and CD4+ T cell counts were maintained for a 24-week period of follow-up.

CONCLUSION:

These results suggest that CNAR plays an important role in suppressing HIV replication in the setting of antiretroviral treatment interruption in HIV-infected individuals.

PMID:
19189205
[PubMed - indexed for MEDLINE]
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