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Intensive Care Med. 2009 Jul;35(7):1240-6. doi: 10.1007/s00134-009-1414-7. Epub 2009 Feb 3.

Short-term evaluation of sedation with sevoflurane administered by the anesthetic conserving device in critically ill patients.

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  • 1Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Monza (MI), Italy.



Assessing feasibility and physiological effects of sedation with sevoflurane, administered with the anesthetic conserving device (AnaConDa), in comparison with propofol and remifentanil.


Seventeen patients undergoing mechanical ventilation underwent sedation with sevoflurane delivered with AnaConDa (phase SevAn), preceded and followed by sedation with propofol and remifentanil (phases ProRe(1), ProRe(2)), with the same sedation targets.


With both strategies it was possible to achieve the sedation targets. Time required to sedate and awake patients was greater during SevAn than ProRe(1): respectively, 3.3 +/- 3.0 versus 8.9 +/- 6.1 and 7.47 +/- 5.05 versus 16.3 +/- 11.4 min. During SevAn the PaCO(2) and minute ventilation increased. Hemodynamics was stable between ProRe(1) and SevAn, except for an increase in heart rate in the SevAn phase. Environmental pollution from sevoflurane was within the safety limits.


Sevoflurane can be effectively and safely used for short-term sedation of ICU patients with stable hemodynamic conditions.

[PubMed - indexed for MEDLINE]
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