J Clin Gastroenterol. 1991 Aug;13(4):411-4.

Myxedema ascites. Report of two cases and review of the literature.

de Castro F, Bonacini M, Walden JM, Schubert TT.

Source

Division of Gastroenterology, University of Missouri-Kansas City School of Medicine, MO 64108.

Abstract

Ascites is a well-known but uncommon occurrence in hypothyroid patients. We describe two patients with clinical ascites that resolved completely on thyroid replacement therapy. Our review of the literature found 21 well-documented cases of myxedema ascites. Prominent features of this condition include a high protein content of the ascitic fluid (greater than 2.5 g/dl), a high albumin serum-ascites gradient, a long duration of the ascites, and its resolution on thyroid replacement. We also found a slight female predominance. The exact mechanisms responsible for ascites accumulation are unknown and some of the hypotheses are discussed. We conclude that ascites associated with hypothyroidism is rare but must be recognized early since thyroid replacement is definitive therapy.

PMID:: 1918846; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Ovid Technologies, Inc.

Molecular Biology Databases

LEVOTHYROXINE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Ascites due to hypothyroidism in a patient with alcoholic cirrhosis. [Acta Gastroenterol Latinoam. 2...]
Ascites due to hypothyroidism in a patient with alcoholic cirrhosis.
Otero Bedoya J, Landeira G, Corino M, Tamashiro A, Fassio E. Acta Gastroenterol Latinoam. 2001 May; 31(2):77-81.
Review Myxedema ascites: case report and literature review. [J Korean Med Sci. 2006]
Review Myxedema ascites: case report and literature review.
Ji JS, Chae HS, Cho YS, Kim HK, Kim SS, Kim CW, Lee CD, Lee BI, Choi H, Lee KM, et al. J Korean Med Sci. 2006 Aug; 21(4):761-4.
Myxedema ascites with an extremely elevated CA125 Level: a case report. [Endocr J. 2007]
Myxedema ascites with an extremely elevated CA125 Level: a case report.
Kanehara H, Bando Y, Tomita M, Kontani M, Takegoshi Y, Tanaka N. Endocr J. 2007 Aug; 54(4):601-4. Epub 2007 Jul 20.
Myxedema ascites with elevated serum CA 125 concentration. [Am J Med Sci. 2006]
Myxedema ascites with elevated serum CA 125 concentration.
Duarte DR, Chang CV, Minicucci MF, Zornoff LA, Inoue RM, Matsui M, Okoshi MP, Azevedo PS, Matsubara LS, Paiva SA. Am J Med Sci. 2006 Feb; 331(2):103-4.
Review Factors associated with mortality of myxedema coma: report of eight cases and literature survey. [Thyroid. 1999]
Review Factors associated with mortality of myxedema coma: report of eight cases and literature survey.
Yamamoto T, Fukuyama J, Fujiyoshi A. Thyroid. 1999 Dec; 9(12):1167-74.

See reviews... See all...

Cited by 2 PubMed Central articles

Review Myxedema ascites: case report and literature review. [J Korean Med Sci. 2006]
Review Myxedema ascites: case report and literature review.
Ji JS, Chae HS, Cho YS, Kim HK, Kim SS, Kim CW, Lee CD, Lee BI, Choi H, Lee KM, et al. J Korean Med Sci. 2006 Aug; 21(4):761-4.
Lesson of the week: Hypothyroidism mimicking intra-abdominal malignancy. [BMJ. 2002]
Lesson of the week: Hypothyroidism mimicking intra-abdominal malignancy.
Krishnan ST, Philipose Z, Rayman G. BMJ. 2002 Oct 26; 325(7370):946-7.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Myxedema ascites. Report of two cases and review of the literature.
Myxedema ascites. Report of two cases and review of the literature.
J Clin Gastroenterol. 1991 Aug ;13(4):411-4.

PubMed
Estrogen receptor alpha represses transcription of early target genes via p300 a...
Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1.
Mol Cell Biol. 2009 Apr ;29(7):1749-59. Epub 2009 Feb 2 .

PubMed
The essential N terminus of the Pta1 scaffold protein is required for snoRNA tra...
The essential N terminus of the Pta1 scaffold protein is required for snoRNA transcription termination and Ssu72 function but is dispensable for pre-mRNA 3'-end processing.
Mol Cell Biol. 2009 Apr ;29(8):2296-307. Epub 2009 Feb 2 .

PubMed
Distinct protein arginine methyltransferases promote ATP-dependent chromatin rem...
Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation.
Mol Cell Biol. 2009 Apr ;29(7):1909-21. Epub 2009 Feb 2 .

PubMed
Functional targets of the monogenic diabetes transcription factors HNF-1alpha an...
Functional targets of the monogenic diabetes transcription factors HNF-1alpha and HNF-4alpha are highly conserved between mice and humans.
Diabetes. 2009 May ;58(5):1245-53. Epub 2009 Feb 2 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: