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Neuron. 2009 Jan 29;61(2):160-7. doi: 10.1016/j.neuron.2009.01.001.

MAP'ing CNS development and cognition: an ERKsome process.

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  • 1Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA.


The ERK MAP kinase signaling cascade plays critical roles in brain development, learning, memory, and cognition. It has recently been appreciated that mutation or deletion of elements within this signaling pathway leads to developmental syndromes in humans that are associated with impaired cognitive function and autism. Here, we review recent studies that provide insight into the biological roles of the ERKs in the brain that may underlie the cognitive deficits seen in these syndromes.

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